PrecisionTox delivered a public comment during the recent meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) (September 11–12, 2025). The comment focused on the importance of including biomedically relevant in vivo models, such as Drosophila, C. elegans, zebrafish embryos, and Daphnia, in the U.S. roadmap for advancing New Approach Methodologies (NAMs) and reducing animal testing. These models have long played a vital role in biomedical discovery and remain critical for mechanism-based toxicology and human health risk assessment. As part of the comment, PrecisionTox urged the U.S. agencies to adopt a similar stance to promote global alignment and ensure that regulatory frameworks keep pace with scientific advances. This is a vital step toward a modern, human-relevant approach to toxicology, one that integrates advanced in vitro systems with non-protected whole-organism models to reduce reliance on animal testing.
Read the complete comment here
