Towards Precision Toxicology

A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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Pillars of the project

Phylotoxicology

Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in
Susceptibility

Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation

Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

News & Press

News

“Revolutionizing Chemical Safety: PrecisionTox Leads the Change” Press Release

Press release: "Revolutionizing Chemical Safety: PrecisionTox Leads the Change"   The PrecisionTox consortium held its third annual meeting in Brussels on June 13-14. The gathering…
News

The PrecisionTox Annual Consortium Meeting is happening this week in Brussels, Belgium!

We are meeting on June 13th & 14th for two action-packed days focused on advancing chemical safety assessment to safeguard human health and the environment.   …
News

Spring Newsletter 2024

Check out our latest newsletter!
News

“There is no regulatory acceptance, but we are advancing in terms of scientific robustness,” ASPIS members shared their insights on the SOT.

“We are approached by undergraduate students who are interested in what ASPIS is doing,” celebrates Jonathan Freedman. If you are part of the toxicology community,…
News
Policy Brief on Socio – Technical Barriers to the Uptake of NAMs
News
Read the Report on Socio-Technical Barriers to the Uptake of NAMs here
News
Winter Newsletter 2023
News
EU project PrecisionTox had breakfast with Member of European Parliament Jutta Paulus (Greens/EFA).
Leveraging NAMs To Achieve 100% Compliance In REACH Dossier