Towards Precision Toxicology

The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project


Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.

Variation in

Determine safe levels of exposure to chemicals based on genetic variation.


Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.

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A new scientific approach

The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.

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News & Press

latest news about Precision Toxicology


Water fleas as ‘canaries in a coal mine’ offer key to managing chemical pollution

Published on September 28, 2022 Abstract Water fleas, or Daphnia, could provide an important 'early warning system' for chemical pollution in our lakes and rivers. In…

Daphnia as a Sentinel Species for Environmental Health Protection: A Perspective on Biomonitoring and Bioremediation of Chemical Pollution

Published on September 28, 2022 Abstract Despite available technology and the knowledge that chemical pollution damages human and ecosystem health, chemical pollution remains rampant, ineffectively…

An illustrator’s daily life struggle to translate science – episode 4

Discover the 3rd episode of our short comic created by @elvixente "An illustrator's struggle"

Summer Newsletter (#4)

The Summer Newsletter is online feedbacks from our consortium meeting great news from Watchfrog an article By Stefan Scholz, Beate I. Escher, et al. the…
Watchfrog Laboratory validates a new method to identify endocrine disruptors
REACH revision: Better chemical safety for a Toxic-free environment
The impact of chemical pollution is too high to be ignored
Increase in Global Deaths From Modern Pollution Offsets Reductions in Pollution Deaths Associated with Extreme Poverty

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