Replace traditional animal testing with an evolutionarily diverse suite of biomedical model organisms from multiple branches of the tree of life.
Towards Precision Toxicology
The goal of PrecisionTox is to improve chemical safety assessment to better protect human health and the environment by using non-traditional test species, multiple fields of knowledge, and powerful computational approaches to understand which chemicals are toxic and why.

Pillars of the project

Phylotoxicology

Variation in
Susceptibility
Determine safe levels of exposure to chemicals based on genetic variation.

Embedded
Translation
Collaborate with regulators and other key stakeholders in project planning, selection of chemicals for investigation, and case studies for applying Precision Toxicology in policy and law.
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A new scientific approach
The aim of the international PrecisionTox project is to better protect the health of people and the environment by establishing New Approach Methodologies (NAMs) for chemical safety testing using a mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. We use human cell lines and a diverse suite of well-established biomedical model organisms — fruit flies, water fleas, round worms, and embryos of frogs and zebrafish — as well as artificial intelligence (AI) approaches to uncover molecular toxicity pathways shared across the animal kingdom. The result is a new regulatory paradigm based on greater certainty at predicting which chemicals cause harm to humans without causing harm to other animals.
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News & Press
latest news about Precision Toxicology
The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment
Stefan Scholz 1, Werner Brack 2 3, Beate I Escher 4 5, Jörg Hackermüller 6 7, Matthias Liess 8 9, Martin von Bergen 10 11, Lukas Y Wick 12, Ana C Zenclussen 13 14, Rolf Altenburger 15 9 Keywords: European Union; Hazard assessment; Risk assessment; Sustainable chemistry.

Launch of the European PARC programme to improve chemical risk assessment
by Jeanne Laperrouze Media Part blog 12 may 2022The European Partnership for Assessment of Risks from Chemicals (PARC), which is being launched on 12 May…

Replacing animal testing: the why and the how
by Jeanne Laperrouze Media Part blog 22 april 202224th of April is observed across the globe as the World Day for Laboratory Animals. This day,…